When it comes to the care of wounds, a common query arises: should I leave gauze in overnight? This question often surfaces in the minds of individuals tasked with managing their own or their loved ones’ injuries. The considerations are manifold, as gauze serves not only as a protective barrier but also as a means to absorb exudate. However, does leaving it in place for extended periods ensure optimal healing, or does it risk creating a breeding ground for bacteria? Moreover, what are the implications for comfort, and how might the type of injury influence this decision? Could overwearing gauze lead to complications such as increased pain or irritation? Are there particular circumstances—like the size or nature of the wound—that necessitate reevaluating the duration for which gauze is left applied? With such a fundamental issue at heart, what evidence exists to inform best practices in wound care regarding overnight gauze retention?