In contemplating the optimal timing for incorporating azelaic acid into one’s skincare regimen, a myriad of questions arise. Should this potent compound, renowned for its multifarious benefits, such as treating acne and hyperpigmentation, be utilized during the morning or the evening? Could the resolution to this query hinge on various factors, including skin type, sensitivity levels, or concurrent use of other products? What implications does the circadian rhythm have on the absorption and efficacy of azelaic acid? Moreover, does exposure to sunlight necessitate a preference for nighttime application to mitigate potential irritation? Could the layering of other active ingredients, possibly in a more elaborate morning routine, influence the decision? As one navigates these considerations, the intricate balance of personal skincare needs and the unique characteristics of azelaic acid beg for further exploration. Is there a definitive answer, or is it an individual journey toward discovering what harmonizes best with one’s skin health objectives?