When considering the application sequence of tretinoin and moisturizer, one might ponder, “Should I apply moisturizer before or after tretinoin?” This query often arises among individuals seeking optimal results from their skincare regimen. Tretinoin, a potent derivative of vitamin A, is renowned for its efficacy in combating acne and mitigating signs of aging. However, given its potential to cause dryness and irritation, the timing of moisturizer application can be pivotal. Should the hydrating agent take precedence to create a soothing barrier, thereby reducing the likelihood of discomfort? Conversely, would applying moisturizer afterward enhance the skin’s absorption of tretinoin, maximizing its transformative benefits? The choice may also hinge on unique skin types, tolerance levels, and personal preferences. Navigating the maze of skincare protocols can be perplexing; thus, it is crucial to discern the most appropriate application strategy to cultivate a healthy, radiant complexion while minimizing adverse reactions. What is your standpoint on this topical conundrum?